Autoimmune Hepatitis (AIH)
Autoimmune hepatitis (AIH) is a rare autoimmune disease where the immune system attacks the liver, causing inflammation that can lead to scarring or liver damage over time.
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Fatigue
Abdominal pain
Joint pain
Jaundice (yellowing of skin and eyes)
Loss of appetite
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Dark (tea colored) urine
Itching
Dry eyes, mouth and nose
There are two main types of AIH, based on the antibodies found in blood tests:
- Type 1 AIH: The most common form, affecting adults and children.
- Type 2 AIH: Less common, usually diagnosed in children and young adults, sometimes more severe.
Diagnosing AIH often requires multiple steps, since its symptoms can look like other liver diseases. The process may include:
Blood tests (to check liver enzymes and autoantibodies)
Imaging tests (such as ultrasound or MRI)
A liver biopsy (to confirm inflammation and damage)
Because AIH is rare, diagnosis may take time and often involves a specialist such as a hepatologist.
Treatment for Autoimmune Hepatitis (AIH) aims to reduce liver inflammation, slow disease progression, and prevent long-term damage.
Common approaches may include:
Corticosteroids (such as prednisone) to decrease liver inflammation
Immunosuppressants (such as azathioprine) to help control immune system activity
Alternative medicines (such as mycophenolate mofetil) for those who cannot tolerate standard therapy
Regular monitoring of liver enzymes and immune markers to guide long-term care
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If autoimmune hepatitis is not diagnosed or treated early, ongoing inflammation can lead to serious liver damage over time. Potential complications include fibrosis (scarring of the liver), cirrhosis, liver failure, and an increased risk of liver cancer. Some people may also develop related autoimmune conditions affecting other organs, such as the thyroid or joints.
Ongoing Research
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Resources
Find an online community of fellow patients, caregivers, and advocates below as
as well as some other general resources!
Community Groups Advocacy Groups Podcasts & Websites Mental Health Resources Research Articles
Autoimmune Hepatitis Support Groups
Peer-led online communities for people living with autoimmune hepatitis, offering daily connection, lived experience, and practical advice.
Reddit Group r/autoimmunehepatitis
Treatment and AIH itself affects everyone differently, and this is the place to get support, answers, and discussions regarding this disease.
American Liver Foundation
The American Liver Foundation provides education, support, and funding for research to improve liver health and awareness across the U.S.
European Association for the Study of the Liver (EASL)
A global community of liver specialists advancing science, treatment, and education related to liver diseases.
Autoimmune Hepatitis Association
Liver Talks
A webinar and video series featuring expert discussions and patient insights about autoimmune liver conditions.
RareCast Global
Explores stories and science behind rare diseases, featuring autoimmune hepatitis.
Mental Health America (MHA)
Mental Health America is committed to promoting mental health and preventing mental illness through advocacy, research, education, and services.
Comprehensive Review Identifies Gaps in AIH Diagnosis and Management
This review summarizes current diagnostic tools, standard treatments, and areas where improved clinical guidelines are needed for earlier, more accurate AIH detection.
Emerging Therapies Aim to Reduce Steroid Dependence in AIH
New trials are exploring therapies designed to minimize long-term corticosteroid use while maintaining remission in autoimmune hepatitis.